Endocrine Abstracts

Maternal nutrient restriction predisposes the adult offspring to metabolic syndrome. We investigated the effect of energy restriction during early or late gestation on glucose-insulin dynamics during a GTT (0.5 g/kg i.v. glucose) and/or an ITT (0.75 IU/kg) prior to and after significant gain in adipose tissue. 20 sheep were either fed to maintenance (1 M; CE, n=6) or to 0.65 M during early (0–65 days, term=147days, LEE, n=7) or late (65–125 days, LEL; <...